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M94A0197.TXT
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1994-10-08
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Document 0197
DOCN M94A0197
TI Actinomyces infection of a cytomegalovirus esophageal ulcer in two
patients with acquired immunodeficiency syndrome.
DT 9412
AU Poles MA; McMeeking AA; Scholes JV; Dieterich DT; New York University
Medical Center, NY.
SO Am J Gastroenterol. 1994 Sep;89(9):1569-72. Unique Identifier : AIDSLINE
MED/94361089
AB Esophageal disease is a significant cause of morbidity among patients
with the acquired immunodeficiency syndrome (AIDS). Many organisms have
been implicated in the pathogenesis of dysphagia and odynophagia. We
describe a unique presentation of actinomyces esophageal infection in
two homosexual male patients with AIDS and biopsy proven CMV
esophagitis. After failure of esophagitis to resolve with ganciclovir or
foscarnet therapy, the patients underwent repeat endoscopy and were
subsequently found to have a secondary infection of the ulcers by
Actinomyces. Treatment with intravenous penicillin G resulted in
symptomatic and histopathological resolution of esophageal disease. This
appears to be the first report of Actinomyces infection of esophageal
ulcers in AIDS patients, possibly a commonly overlooked diagnosis.
DE Actinomycosis/*DIAGNOSIS/DRUG THERAPY Adult AIDS-Related Opportunistic
Infections/DIAGNOSIS/DRUG THERAPY/ *MICROBIOLOGY Case Report
Cytomegalovirus Infections/*DIAGNOSIS/DRUG THERAPY Esophageal Cyst/DRUG
THERAPY/*MICROBIOLOGY Esophagitis/DRUG THERAPY/MICROBIOLOGY
Foscarnet/THERAPEUTIC USE Ganciclovir/THERAPEUTIC USE Human Male
Penicillin G/THERAPEUTIC USE JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).